Journal of Pathology and Translational Medicine

Original Articles

Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma: Sumi Yun, Ping-Li Sun, Yan Jin, Hyojin Kim, Eunhyang Park, Soo Young Park, Kyuho Lee, Kyoungyul Lee, Jin-Haeng Chung; J Pathol Transl Med. 2016;50(4):251-257. Published online June 7, 2016; DOI: https://doi.org/10.4132/jptm.2016.03.30

9,273 View
118 Download
19 Web of Science
17 Crossref

Background
Aquaporin 1 (AQP1) overexpression has been shown to be associated with uncontrolled cell replication, invasion, migration, and tumor metastasis. We aimed to evaluate AQP1 expression in lung adenocarcinomas and to examine its association with clinicopathological features and prognostic significance. We also investigated the association between AQP1 overexpression and epithelial-mesenchymal transition (EMT) markers.
Methods
We examined AQP1 expression in 505 cases of surgically resected lung adenocarcinomas acquired at the Seoul National University Bundang Hospital from 2003 to 2012. Expression of AQP1 and EMT-related markers, including Ecadherin and vimentin, were analyzed by immunohistochemistry and tissue microarray.
Results
AQP1 overexpression was associated with several aggressive pathological parameters, including venous invasion, lymphatic invasion, and tumor recurrence. AQP1 overexpression tended to be associated with higher histological grade, advanced pathological stage, and anaplastic lymphoma kinase (ALK) translocation; however, these differences were not statistically significant. In addition, AQP1 overexpression positively correlated with loss of E-cadherin expression and acquired expression of vimentin. Lung adenocarcinoma patients with AQP1 overexpression showed shorter progression- free survival (PFS, 46.1 months vs. 56.2 months) compared to patients without AQP1 overexpression. Multivariate analysis confirmed that AQP1 overexpression was significantly associated with shorter PFS (hazard ratio, 1.429; 95% confidence interval, 1.033 to 1.977; p=.031).
Conclusions
AQP1 overexpression was thereby concluded to be an independent factor of poor prognosis associated with shorter PFS in lung adenocarcinoma. These results suggested that AQP1 overexpression might be considered as a prognostic biomarker of lung adenocarcinoma.

Citations

Citations to this article as recorded by

Aquaporins in Cancer Biology
Chul So Moon, David Moon, Sung Koo Kang
Frontiers in Oncology.2022;[Epub] CrossRef
A Comprehensive Prognostic Analysis of Tumor-Related Blood Group Antigens in Pan-Cancers Suggests That SEMA7A as a Novel Biomarker in Kidney Renal Clear Cell Carcinoma
Yange Wang, Chenyang Li, Xinlei Qi, Yafei Yao, Lu Zhang, Guosen Zhang, Longxiang Xie, Qiang Wang, Wan Zhu, Xiangqian Guo
International Journal of Molecular Sciences.2022; 23(15): 8799. CrossRef
Differential modulation of lung aquaporins among other pathophysiological markers in acute (Cl2 gas) and chronic (carbon nanoparticles, cigarette smoke) respiratory toxicity mouse models
Sukanta S. Bhattacharya, Brijesh Yadav, Ekta Yadav, Ariel Hus, Niket Yadav, Perminder Kaur, Lauren Rosen, Roman Jandarov, Jagjit S. Yadav
Frontiers in Physiology.2022;[Epub] CrossRef
Aquaporin water channels as regulators of cell-cell adhesion proteins
Sarannya Edamana, Frédéric H. Login, Soichiro Yamada, Tae-Hwan Kwon, Lene N. Nejsum
American Journal of Physiology-Cell Physiology.2021; 320(5): C771. CrossRef
Targeting Aquaporins in Novel Therapies for Male and Female Breast and Reproductive Cancers
Sidra Khan, Carmela Ricciardelli, Andrea J. Yool
Cells.2021; 10(2): 215. CrossRef
Targeting ion channels for the treatment of lung cancer
Liqin Zhang, Shuya Bing, Mo Dong, Xiaoqiu Lu, Yuancheng Xiong
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer.2021; 1876(2): 188629. CrossRef
Comprehensive Analysis of Aquaporin Superfamily in Lung Adenocarcinoma
Guofu Lin, Luyang Chen, Lanlan Lin, Hai Lin, Zhifeng Guo, Yingxuan Xu, Chanchan Hu, Jinglan Fu, Qinhui Lin, Wenhan Chen, Yiming Zeng, Yuan Xu
Frontiers in Molecular Biosciences.2021;[Epub] CrossRef
Aquaporin 1, 3, and 5 Patterns in Salivary Gland Mucoepidermoid Carcinoma: Expression in Surgical Specimens and an In Vitro Pilot Study
Mérin Barbara Stamboni, Ágatha Nagli de Mello Gomes, Milena Monteiro de Souza, Katia Klug Oliveira, Claudia Fabiana Joca Arruda, Fernanda de Paula, Barbara Beltrame Bettim, Márcia Martins Marques, Luiz Paulo Kowalski, Clóvis Antônio Lopes Pinto, Victor El
International Journal of Molecular Sciences.2020; 21(4): 1287. CrossRef
Combined Systematic Review and Transcriptomic Analyses of Mammalian Aquaporin Classes 1 to 10 as Biomarkers and Prognostic Indicators in Diverse Cancers
Pak Hin Chow, Joanne Bowen, Andrea J Yool
Cancers.2020; 12(7): 1911. CrossRef
Aquaporins in lung health and disease: Emerging roles, regulation, and clinical implications
Ekta Yadav, Niket Yadav, Ariel Hus, Jagjit S. Yadav
Respiratory Medicine.2020; 174: 106193. CrossRef
Dissecting gene‐environment interactions: A penalized robust approach accounting for hierarchical structures
Cen Wu, Yu Jiang, Jie Ren, Yuehua Cui, Shuangge Ma
Statistics in Medicine.2018; 37(3): 437. CrossRef
Immunohistochemical Expression of Aquaporin-1 in Fluoro-Edenite-Induced Malignant Mesothelioma: A Preliminary Report
Giuseppe Angelico, Rosario Caltabiano, Carla Loreto, Antonio Ieni, Giovanni Tuccari, Caterina Ledda, Venerando Rapisarda
International Journal of Molecular Sciences.2018; 19(3): 685. CrossRef
Mechanisms of Aquaporin-Facilitated Cancer Invasion and Metastasis
Michael L. De Ieso, Andrea J. Yool
Frontiers in Chemistry.2018;[Epub] CrossRef
Aquaporin 1 suppresses apoptosis and affects prognosis in esophageal squamous cell carcinoma
Yuzo Yamazato, Atsushi Shiozaki, Daisuke Ichikawa, Toshiyuki Kosuga, Katsutoshi Shoda, Tomohiro Arita, Hirotaka Konishi, Shuhei Komatsu, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Eiichi Konishi, Yoshinori Marunaka, Eigo Otsuji
Oncotarget.2018; 9(52): 29957. CrossRef
Aquaporin 1 expression is associated with response to adjuvant chemotherapy in stageï¿½II and III colorectal cancer
Hideko Imaizumi, Keiichiro Ishibashi, Seiichi Takenoshita, Hideyuki Ishida
Oncology Letters.2018;[Epub] CrossRef
Aquaporin 3 facilitates tumor growth in pancreatic cancer by modulating mTOR signaling
Xunwei Huang, Li Huang, Minhua Shao
Biochemical and Biophysical Research Communications.2017; 486(4): 1097. CrossRef
Prognostic implication of aquaporin 1 overexpression in resected lung adenocarcinoma†
Guido Bellezza, Jacopo Vannucci, Fortunato Bianconi, Giulio Metro, Rachele Del Sordo, Marco Andolfi, Ivana Ferri, Paola Siccu, Vienna Ludovini, Francesco Puma, Angelo Sidoni, Lucio Cagini
Interactive CardioVascular and Thoracic Surgery.2017; 25(6): 856. CrossRef

Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma: Eunhyang Park, Soo Young Park, Hyojin Kim, Ping-Li Sun, Yan Jin, Suk Ki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung; J Pathol Transl Med. 2015;49(5):382-388. Published online August 4, 2015; DOI: https://doi.org/10.4132/jptm.2015.07.10

7,782 View
74 Download
22 Web of Science
17 Crossref

Abstract PDF

Background
Insulin-like growth factor-1 receptor (IGF1R) is a membrane receptor-type tyrosine kinase that has attracted considerable attention as a potential therapeutic target, although its clinical significance in non-small cell lung cancer (NSCLC) is controversial. This study aimed to clarify the clinical significance of IGF1R expression in human NSCLC. Methods: IGF1R protein expression was evaluated using immunohistochemistry in 372 patients with NSCLC who underwent curative surgical resection (146 squamous cell carcinomas [SqCCs] and 226 adenocarcinomas [ADCs]). We then analyzed correlations between expression of IGF1R and clinicopathological and molecular features and prognostic significance. Results: Membranous and cytoplasmic IGF1R expression were significantly higher in SqCCs than in ADCs. In patients with SqCC, membranous IGF1R expression was associated with absence of vascular, lymphatic, and perineural invasion; lower stage; and better progression-free survival (PFS) (hazard ratio [HR], 0.586; p = .040). In patients with ADC, IGF1R expression did not have a significant prognostic value; however, in the subgroup of epidermal growth factor receptor (EGFR)-mutant ADC, membranous IGF1R expression was associated with lymphatic and perineural invasion, solid predominant histology, and higher cancer stage and was significantly associated with worse PFS (HR, 2.582; p = .009). Conclusions: Lung ADC and SqCC showed distinct IGF1R expression profiles that demonstrated prognostic significance. High membranous IGF1R expression was predictive of poor PFS in EGFR-mutant lung ADC, while it was predictive of better PFS in SqCC. These findings will help improve study design for subsequent investigations and select patients for future anti-IGF1R therapy.

Citations

Citations to this article as recorded by

Expression of Amine Oxidase Proteins in Adrenal Cortical Neoplasm and Pheochromocytoma
Eun Kyung Kim, Ja Seung Koo
Biomedicines.2023; 11(7): 1896. CrossRef
Expression of EMP 1, 2, and 3 in Adrenal Cortical Neoplasm and Pheochromocytoma
Yoon Jin Cha, Ja Seung Koo
International Journal of Molecular Sciences.2023; 24(16): 13016. CrossRef
Clinico-pathological characteristics of IGFR1 and VEGF-A co-expression in early and locally advanced-stage lung adenocarcinoma
Wenting Liu, Junling Xia, Qingwu Du, Jingya Wang, Ting Mei, Tingting Qin
Journal of Cancer Research and Clinical Oncology.2023; 149(18): 16365. CrossRef
NT157 exerts antineoplastic activity by targeting JNK and AXL signaling in lung cancer cells
Lívia Bassani Lins de Miranda, Keli Lima, Juan Luiz Coelho-Silva, Fabiola Traina, Susumu S. Kobayashi, João Agostinho Machado-Neto
Scientific Reports.2022;[Epub] CrossRef
IRS2 Amplification as a Predictive Biomarker in Response to Ceritinib in Small Cell Lung Cancer
Mi-Sook Lee, Kyungsoo Jung, Ji-Young Song, Min-Jung Sung, Sung-Bin Ahn, Boram Lee, Doo-Yi Oh, Yoon-La Choi
Molecular Therapy - Oncolytics.2020; 16: 188. CrossRef
Understanding Lineage Plasticity as a Path to Targeted Therapy Failure in EGFR-Mutant Non-small Cell Lung Cancer
Tatiana Shaurova, Letian Zhang, David W. Goodrich, Pamela A. Hershberger
Frontiers in Genetics.2020;[Epub] CrossRef
Characterization of head and neck squamous cell carcinoma arising in young patients: Particular focus on molecular alteration and tumor immunity
Hyang Joo Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Head & Neck.2019; 41(1): 198. CrossRef
Investigating Trk Protein Expression between Oropharyngeal and Non-oropharyngeal Squamous Cell Carcinoma: Clinical Implications and Possible Roles of Human Papillomavirus Infection
Yoon Ah Cho, Ji Myung Chung, Hyunmi Ryu, Eun Kyung Kim, Byoung Chul Cho, Sun Och Yoon
Cancer Research and Treatment.2019; 51(3): 1052. CrossRef
NOVA1 induction by inflammation and NOVA1 suppression by epigenetic regulation in head and neck squamous cell carcinoma
Eun Kyung Kim, Yoon Ah Cho, Mi-kyoung Seo, Hyunmi Ryu, Byoung Chul Cho, Yoon Woo Koh, Sun Och Yoon
Scientific Reports.2019;[Epub] CrossRef
Advances in studies of tyrosine kinase inhibitors and their acquired resistance
Qinlian Jiao, Lei Bi, Yidan Ren, Shuliang Song, Qin Wang, Yun-shan Wang
Molecular Cancer.2018;[Epub] CrossRef
The long coding RNA AFAP1-AS1 promotes tumor cell growth and invasion in pancreatic cancer through upregulating the IGF1R oncogene via sequestration of miR-133a
Bo Chen, Qinhua Li, Yongping Zhou, Xujing Wang, Qiqi Zhang, Yongkun Wang, Huiren Zhuang, Xiaohua Jiang, Wujun Xiong
Cell Cycle.2018; 17(16): 1949. CrossRef
Overexpression of lncRNA EGFR‑AS1 is associated with a poor prognosis and promotes chemotherapy resistance in non‑small cell lung cancer
Yu-Hua Xu, Jian-Ren Tu, Tian-Tian Zhao, Shi-Guang Xie, Sheng-Bo Tang
International Journal of Oncology.2018;[Epub] CrossRef
IGF-IR signaling in epithelial to mesenchymal transition and targeting IGF-IR therapy: overview and new insights
Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang, Yunpeng Liu
Molecular Cancer.2017;[Epub] CrossRef
Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival
Mojca Humar, Izidor Kern, Gregor Vlacic, Vedran Hadzic, Tanja Cufer
Radiology and Oncology.2017; 51(2): 195. CrossRef
IGF1R depletion facilitates MET-amplification as mechanism of acquired resistance to erlotinib in HCC827 NSCLC cells
Dianna Hussmann, Anne Tranberg Madsen, Kristine Raaby Jakobsen, Yonglun Luo, Boe Sandahl Sorensen, Anders Lade Nielsen
Oncotarget.2017; 8(20): 33300. CrossRef
Upregulated Neuro-oncological Ventral Antigen 1 (NOVA1) Expression Is Specific to Mature and Immature T- and NK-Cell Lymphomas
Eun Kyung Kim, Sun Och Yoon, Soo Hee Kim, Woo Ick Yang, Yoon Ah Cho, Soo Jeong Kim
Journal of Pathology and Translational Medicine.2016; 50(2): 104. CrossRef
The Clinical Significance of the Insulin-Like Growth Factor-1 Receptor Polymorphism in Non-Small-Cell Lung Cancer with Epidermal Growth Factor Receptor Mutation
Tu-Chen Liu, Ming-Ju Hsieh, Ming-Che Liu, Whei-Ling Chiang, Thomas Tsao, Shun-Fa Yang
International Journal of Molecular Sciences.2016; 17(5): 763. CrossRef

Comparison of Direct Sequencing, PNA Clamping-Real Time Polymerase Chain Reaction, and Pyrosequencing Methods for the Detection of EGFR Mutations in Non-small Cell Lung Carcinoma and the Correlation with Clinical Responses to EGFR Tyrosin: Hyun Ju Lee, Xianhua Xu, Hyojin Kim, Yan Jin, Pingli Sun, Ji Eun Kim, Jin-Haeng Chung; Korean J Pathol. 2013;47(1):52-60. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.52

10,184 View
70 Download
31 Crossref

Abstract PDF

Background

The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).

Methods

Sixty-one NSCLC patients treated with EGFR TKIs were identified to investigate somatic mutations in the EGFR gene (exons 18-21).

Results

Mutations in the EGFR gene were detected in 38 of the 61 patients (62%) by DS, 35 (57%) by PNA clamping and 37 (61%) by pyrosequencing. A total of 44 mutations (72%) were found by at least one of the three methods, and the concordances among the results were relatively high (82-85%; kappa coefficient, 0.713 to 0.736). There were 15 discordant cases (25%) among the three different methods.

Conclusions

All three EGFR mutation tests had good concordance rates (over 82%) for FFPE samples. These results suggest that if the DNA quality and enrichment of tumor cells are assured, then DS, PNA clamping, and pyrosequencing are appropriate methods for the detection of EGFR mutations.

Citations

Citations to this article as recorded by

Recent Trends of Lung Cancer in Korea
Jae Guk Lee, Ho Cheol Kim, Chang-Min Choi
Tuberculosis and Respiratory Diseases.2021; 84(2): 89. CrossRef
Predictive value of KRAS mutation and excision repair cross-complementing 1 (ERCC1) protein overexpression in patients with colorectal cancer administered FOLFOX regimen
Sun Min Park, Sung Bong Choi, Yoon Suk Lee, In Kyu Lee
Asian Journal of Surgery.2021; 44(5): 715. CrossRef
Recent advances in diagnostic technologies in lung cancer
Hye Jung Park, Sang Hoon Lee, Yoon Soo Chang
The Korean Journal of Internal Medicine.2020; 35(2): 257. CrossRef
Afatinib is effective in the treatment of lung adenocarcinoma with uncommon EGFR p.L747P and p.L747S mutations
Sheng-Kai Liang, Jen-Chung Ko, James Chih-Hsin Yang, Jin-Yuan Shih
Lung Cancer.2019; 133: 103. CrossRef
Biomarker Testing for Patients With Advanced Non–Small Cell Lung Cancer: Real-World Issues and Tough Choices
Nathan A. Pennell, Maria E. Arcila, David R. Gandara, Howard West
American Society of Clinical Oncology Educational Book.2019; (39): 531. CrossRef
Evaluation of EGFR mutations in NSCLC with highly sensitive droplet digital PCR assays
Xi‑Wen Jiang, Wei Liu, Xiao‑Ya Zhu, Xiao‑Xie Xu
Molecular Medicine Reports.2019;[Epub] CrossRef
Peptide Nucleic Acid Clamping and Direct Sequencing in the Detection of Oncogenic Alterations in Lung Cancer: Systematic Review and Meta-Analysis
Jae-Uk Song, Jonghoo Lee
Yonsei Medical Journal.2018; 59(2): 211. CrossRef
Distribution of KRAS, DDR2, and TP53 gene mutations in lung cancer: An analysis of Iranian patients
Zahra Fathi, Seyed Ali Javad Mousavi, Raheleh Roudi, Farideh Ghazi, Sumitra Deb
PLOS ONE.2018; 13(7): e0200633. CrossRef
EGFR T790M mutation testing within the osimertinib AURA Phase I study
Simon Dearden, Helen Brown, Suzanne Jenkins, Kenneth S. Thress, Mireille Cantarini, Rebecca Cole, Malcolm Ranson, Pasi A. Jänne
Lung Cancer.2017; 109: 9. CrossRef
Molecular Testing of Lung Cancers
Hyo Sup Shim, Yoon-La Choi, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Mee Sook Roh, Tae-Jung Kim, Seung Yeon Ha, Jin-Haeng Chung, Se Jin Jang, Geon Kook Lee
Journal of Pathology and Translational Medicine.2017; 51(3): 242. CrossRef
Mutations of the Epidermal Growth Factor Receptor Gene in Triple-Negative Breast Cancer
Aeri Kim, Min Hye Jang, Soo Jung Lee, Young Kyung Bae
Journal of Breast Cancer.2017; 20(2): 150. CrossRef
Double primary lung adenocarcinoma diagnosed by epidermal growth factor receptor mutation status
Oh Jung Kwon, Min Hyeok Lee, Sung Ju Kang, Seul Gi Kim, In Beom Jeong, Ji Yun Jeong, Eun Jung Cha, Do Yeun Cho, Young Jin Kim, Ji Woong Son
Yeungnam University Journal of Medicine.2017; 34(2): 270. CrossRef
Generation of lung cancer cell lines harboring EGFR T790M mutation by CRISPR/Cas9-mediated genome editing
Mi-Young Park, Min Hee Jung, Eun Young Eo, Seokjoong Kim, Sang Hoon Lee, Yeon Joo Lee, Jong Sun Park, Young Jae Cho, Jin Haeng Chung, Cheol Hyeon Kim, Ho Il Yoon, Jae Ho Lee, Choon-Taek Lee
Oncotarget.2017; 8(22): 36331. CrossRef
Comparison of EGFR mutation detection between the tissue and cytology using direct sequencing, pyrosequencing and peptide nucleic acid clamping in lung adenocarcinoma: Korean multicentre study
Kyueng-Whan Min, Wan-Seop Kim, Se Jin Jang, Yoo Duk Choi, Sunhee Chang, Soon Hee Jung, Lucia Kim, Mee Sook Roh, Choong Sik Lee, Jung Weon Shim, Mi Jin Kim, Geon Kook Lee
QJM.2016; 109(3): 167. CrossRef
Epidermal Growth Factor Receptor Mutation and Anaplastic Lymphoma Kinase Gene Fusion: Detection in Malignant Pleural Effusion by RNA or PNA Analysis
Yi-Lin Chen, Chung-Ta Lee, Cheng-Chan Lu, Shu-Ching Yang, Wan-Li Chen, Yang-Cheng Lee, Chung-Hsien Yang, Shu-Ling Peng, Wu-Chou Su, Nan-Haw Chow, Chung-Liang Ho, Javier S Castresana
PLOS ONE.2016; 11(6): e0158125. CrossRef
IDH Mutation Analysis in Ewing Sarcoma Family Tumors
Ki Yong Na, Byeong-Joo Noh, Ji-Youn Sung, Youn Wha Kim, Eduardo Santini Araujo, Yong-Koo Park
Journal of Pathology and Translational Medicine.2015; 49(3): 257. CrossRef
Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer
XIANHUA XU, JI EUN KIM, PING-LI SUN, SEOL BONG YOO, HYOJIN KIM, YAN JIN, JIN-HAENG CHUNG
Experimental and Therapeutic Medicine.2015; 9(2): 311. CrossRef
Detection of EGFR-TK Domain–activating Mutations in NSCLC With Generic PCR-based Methods
Rajendra B. Shahi, Sylvia De Brakeleer, Jacques De Grève, Caroline Geers, Peter In’t Veld, Erik Teugels
Applied Immunohistochemistry & Molecular Morphology.2015; 23(3): 163. CrossRef
Frequent aerogenous spread with decreased E-cadherin expression of ROS1- rearranged lung cancer predicts poor disease-free survival
Yan Jin, Ping-Li Sun, Soo Young Park, Hyojin Kim, Eunhyang Park, Gilhyang Kim, Sukki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
Lung Cancer.2015; 89(3): 343. CrossRef
Membranous Insulin-like Growth Factor-1 Receptor (IGF1R) Expression Is Predictive of Poor Prognosis in Patients with Epidermal Growth Factor Receptor (EGFR)-Mutant Lung Adenocarcinoma
Eunhyang Park, Soo Young Park, Hyojin Kim, Ping-Li Sun, Yan Jin, Suk Ki Cho, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
Journal of Pathology and Translational Medicine.2015; 49(5): 382. CrossRef
Peptide Nucleic Acid Clamping Versus Direct Sequencing for the Detection of EGFR Gene Mutation in Patients with Non-small Cell Lung Cancer
Seong-Hoon Yoon, Yoo-Duk Choi, In-Jae Oh, Kyu-Sik Kim, Hayoung Choi, Jinsun Chang, Hong-Joon Shin, Cheol-Kyu Park, Young-Chul Kim
Cancer Research and Treatment.2015; 47(4): 661. CrossRef
Analysis of Mutations in Epidermal Growth Factor Receptor Gene in Korean Patients with Non-small Cell Lung Cancer: Summary of a Nationwide Survey
Sang Hwa Lee, Wan Seop Kim, Yoo Duk Choi, Jeong Wook Seo, Joung Ho Han, Mi Jin Kim, Lucia Kim, Geon Kook Lee, Chang Hun Lee, Mee Hye Oh, Gou Young Kim, Sun Hee Sung, Kyo Young Lee, Sun Hee Chang, Mee Sook Rho, Han Kyeom Kim, Soon Hee Jung, Se Jin Jang
Journal of Pathology and Translational Medicine.2015; 49(6): 481. CrossRef
Novel EGFR mutation-specific antibodies for lung adenocarcinoma: Highly specific but not sensitive detection of an E746_A750 deletion in exon 19 and an L858R mutation in exon 21 by immunohistochemistry
An Na Seo, Tae-In Park, Yan Jin, Ping-Li Sun, Hyojin Kim, Hyun Chang, Jin-Haeng Chung
Lung Cancer.2014; 83(3): 316. CrossRef
Simultaneous diagnostic platform of genotyping EGFR, KRAS, and ALK in 510 Korean patients with non‐small‐cell lung cancer highlights significantly higher ALK rearrangement rate in advanced stage
Tae‐Jung Kim, Chan Kwon Park, Chang Dong Yeo, Kihoon Park, Chin Kook Rhee, Jusang Kim, Seung Joon Kim, Sang Haak Lee, Kyo‐Young Lee, Hyoung‐Kyu Yoon
Journal of Surgical Oncology.2014; 110(3): 245. CrossRef
Epidermal growth factor receptor mutations and anaplastic lymphoma kinase rearrangements in lung cancer with nodular ground-glass opacity
Sung-Jun Ko, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Jin-Haeng Chung, Tae Jung Kim, Kyung Won Lee, Kwhanmien Kim, Sanghoon Jheon, Hyojin Kim, Jae Ho Lee, Choon-Taek Lee
BMC Cancer.2014;[Epub] CrossRef
Cytoplasmic YAP Expression is Associated with Prolonged Survival in Patients with Lung Adenocarcinomas and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Treatment
Ping-Li Sun, Ji Eun Kim, Seol Bong Yoo, Hyojin Kim, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung
Annals of Surgical Oncology.2014; 21(S4): 610. CrossRef
Sensitive methods for detection of the S768R substitution in exon 18 of the DDR2 gene in patients with central nervous system metastases of non-small cell lung cancer
Marcin Nicoś, Tomasz Powrózek, Paweł Krawczyk, Bożena Jarosz, Beata Pająk, Marek Sawicki, Krzysztof Kucharczyk, Tomasz Trojanowski, Janusz Milanowski
Medical Oncology.2014;[Epub] CrossRef
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas
A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
British Journal of Cancer.2014; 110(11): 2688. CrossRef
KRASMutation Detection in Non-small Cell Lung Cancer Using a Peptide Nucleic Acid-Mediated Polymerase Chain Reaction Clamping Method and Comparative Validation with Next-Generation Sequencing
Boram Lee, Boin Lee, Gangmin Han, Mi Jung Kwon, Joungho Han, Yoon-La Choi
Korean Journal of Pathology.2014; 48(2): 100. CrossRef
Guideline Recommendations forEGFRMutation Testing in Lung Cancer: Proposal of the Korean Cardiopulmonary Pathology Study Group
Hyo Sup Shim, Jin-Haeng Chung, Lucia Kim, Sunhee Chang, Wan-Seop Kim, Geon Kook Lee, Soon-Hee Jung, Se Jin Jang
Korean Journal of Pathology.2013; 47(2): 100. CrossRef
Immunohistochemical Classification of Primary and Secondary Glioblastomas
Kyu Sang Lee, Gheeyoung Choe, Kyung Han Nam, An Na Seo, Sumi Yun, Kyung Ju Kim, Hwa Jin Cho, Sung Hye Park
Korean Journal of Pathology.2013; 47(6): 541. CrossRef

Alteration of the E-Cadherin/β-Catenin Complex Is an Independent Poor Prognostic Factor in Lung Adenocarcinoma: Hyojin Kim, Seol Bong Yoo, Pingli Sun, Yan Jin, Sanghoon Jheon, Choon Taek Lee, Jin-Haeng Chung; Korean J Pathol. 2013;47(1):44-51. Published online February 25, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.1.44

9,809 View
44 Download
35 Crossref

Abstract PDF

Background

Epithelial-mesenchymal transition (EMT) is an important step in the invasion and progression of cancer and in the development of chemoresistance by cancer cells.

Methods

To address the clinical significance of the EMT pathway in lung adenocarcinoma and the association of the pathway with histological subtype, we examined 193 surgically resected lung adenocarcinoma samples for the expression of representative EMT-related proteins (E-cadherin, β-catenin, and vimentin) by immunohistochemistry. Histological subtypes were classified according to the 2011 International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society classification. The results for EMT-related protein expression were analyzed for correlation with clinicopathological features and with survival.

Results

The loss of E-cadherin expression and aberrant β-catenin expression were significantly associated with larger tumor size, pleural invasion, lymphatic/vascular invasion, and advanced pathological stage (p<0.05). The alteration of the E-cadherin/β-catenin complex was least frequently observed in the lepidic-predominant group, but these associations were not statistically significant. In the multivariate analysis, altered E-cadherin/β-catenin complex expression was found to be an independent poor prognostic factor (p=0.017; hazard ratio, 1.926; 95% confidence interval, 1.119 to 3.314).

Conclusions

The alteration of the expression of the E-cadherin/β-catenin complex was associated with aggressive tumor behavior in lung adenocarcinoma.

Citations

Citations to this article as recorded by

Prognostic significance of stem cell-related marker expression and its correlation with histologic subtypes in lung adenocarcinoma
Eunhyang Park, Soo Young Park, Ping-Li Sun, Yan Jin, Ji Eun Kim, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Hyojin Kim, Jin-Haeng Chung
Oncotarget.2106; 7(27): 42502. CrossRef
Epigenetic Alterations of DNA Methylation and miRNA Contribution to Lung Adenocarcinoma
Wenhan Cai, Miao Jing, Jiaxin Wen, Hua Guo, Zhiqiang Xue
Frontiers in Genetics.2022;[Epub] CrossRef
Clinicopathological significance and prognostic value of E-cadherin expression in non-small cell lung cancer
Dong Chao, Gawei Hu, Qingxin Li
Medicine.2021; 100(7): e24748. CrossRef
Aberrant Expression of β-Catenin Correlates with Infiltrating Immune Cells and Prognosis in NSCLC
Hongmei Zheng, Yue Ning, Yang Yang, Yuting Zhan, Haihua Wang, Qiuyuan Wen, Jinwu Peng, Songqing Fan
Pathology and Oncology Research.2021;[Epub] CrossRef
Prognostic Significance of Wnt1, Wnt2, E-Cadherin, and β-catenin Expression in Operable Non-small Cell Lung Cancer
Anna Wrona, Aleksandra Sejda, Rafał Dziadziuszko, Jacek Jassem
Journal of Histochemistry & Cytochemistry.2021; 69(11): 711. CrossRef
Analysis of genes associated with prognosis of lung adenocarcinoma based on GEO and TCGA databases
Ye Yu, Xuemei Tian
Medicine.2020; 99(19): e20183. CrossRef
The roles of TG-interacting factor in cadmium exposure-promoted invasion and migration of lung cancer cells
Yadong Wang, Li Shi, Jiangmin Li, Haiyu Wang, Haiyan Yang
Toxicology in Vitro.2019; 61: 104630. CrossRef
Pizotifen inhibits the proliferation and invasion of gastric cancer cells
Ying Jiang, Wei Wang, Xi Wu, Jihua Shi
Experimental and Therapeutic Medicine.2019;[Epub] CrossRef
SNAI2 and TWIST1 in lymph node progression in early stages of NSCLC patients
Camille Emprou, Pauline Le Van Quyen, Jérémie Jégu, Nathalie Prim, Noëlle Weingertner, Eric Guérin, Erwan Pencreach, Michèle Legrain, Anne‐Claire Voegeli, Charlotte Leduc, Bertrand Mennecier, Pierre‐Emmanuel Falcoz, Anne Olland, Nicolas Santelmo, Elisabet
Cancer Medicine.2018; 7(7): 3278. CrossRef
E-Cadherin Loss Accelerates Tumor Progression and Metastasis in a Mouse Model of Lung Adenocarcinoma
Kerstin W. Sinkevicius, Kelly J. Bellaria, Juliana Barrios, Patrizia Pessina, Manav Gupta, Christine Fillmore Brainson, Roderick T. Bronson, Carla F. Kim
American Journal of Respiratory Cell and Molecular Biology.2018; 59(2): 237. CrossRef
Downregulation of peroxiredoxin II suppresses the proliferation and metastasis of gastric cancer cells
Linjun Niu, Ang Liu, Wei Xu, Liang Yang, Wugang Zhu, Yuming Gu
Oncology Letters.2018;[Epub] CrossRef
Implications of NOVA1 suppression within the microenvironment of gastric cancer: association with immune cell dysregulation
Eun Kyung Kim, Sun Och Yoon, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi, Woo Ick Yang
Gastric Cancer.2017; 20(3): 438. CrossRef
High FDG uptake on PET is associated with negative cell-to-cell adhesion molecule E-cadherin expression in lung adenocarcinoma
Kotaro Higashi, Yoshimichi Ueda, Miyako Shimasaki, Yasuhito Ishigaki, Yuka Nakamura, Manabu Oguchi, Tsutomu Takegami, Naoto Watanabe
Annals of Nuclear Medicine.2017; 31(8): 590. CrossRef
MicroRNA expression profiles and clinicopathological implications in lung adenocarcinoma according to EGFR, KRAS, and ALK status
Hyojin Kim, Jeong Mi Yang, Yan Jin, Sanghoon Jheon, Kwhanmien Kim, Choon Taek Lee, Jin-Haeng Chung, Jin Ho Paik
Oncotarget.2017; 8(5): 8484. CrossRef
A meta-analysis of abnormal β-catenin immunohistochemical expression as a prognostic factor in lung cancer: location is more important
Y. Yang, J. Shen, Jiaxi He, Jianxing He, G. Jiang
Clinical and Translational Oncology.2016; 18(7): 685. CrossRef
Aquaporin 1 Is an Independent Marker of Poor Prognosis in Lung Adenocarcinoma
Sumi Yun, Ping-Li Sun, Yan Jin, Hyojin Kim, Eunhyang Park, Soo Young Park, Kyuho Lee, Kyoungyul Lee, Jin-Haeng Chung
Journal of Pathology and Translational Medicine.2016; 50(4): 251. CrossRef
Prognostic Values of Vimentin Expression and Its Clinicopathological Significance in Non-Small Cell Lung Cancer: A Meta-Analysis of Observational Studies with 4118 Cases
Zhihua Ye, Xin Zhang, Yihuan Luo, Shikang Li, Lanshan Huang, Zuyun Li, Ping Li, Gang Chen, Aamir Ahmad
PLOS ONE.2016; 11(9): e0163162. CrossRef
Myoferlin expression in non-small cell lung cancer: Prognostic role and correlation with VEGFR-2 expression
DAE HYUN SONG, GYUNG HYUCK KO, JEONG HEE LEE, JONG SIL LEE, GYEONG-WON LEE, HYEON CHEOL KIM, JUNG WOOK YANG, ROK WON HEO, GU SEOB ROH, SUN-YOUNG HAN, DONG CHUL KIM
Oncology Letters.2016; 11(2): 998. CrossRef
Short hairpin RNA silencing of TGF-βRII and FZD-7 synergistically suppresses proliferation and metastasis of hepatocellular carcinoma cells
CONG CHEN, YUYANG XUE, DEJUN ZHANG, WEI XU, HAO XU, HONG YAO, DONGSHENG PEI, YUMING GU
Oncology Letters.2016; 11(3): 2039. CrossRef
NOVA1 inhibition by miR-146b-5p in the remnant tissue microenvironment defines occult residual disease after gastric cancer removal
Sun Och Yoon, Eun Kyung Kim, Mira Lee, Woon Yong Jung, Hyunjoo Lee, Youngran Kang, You-Jin Jang, Soon Won Hong, Seung Ho Choi, Woo Ick Yang
Oncotarget.2016; 7(3): 2475. CrossRef
Immunohistochemical demonstration of alteration of β-catenin during tumor metastasis by different mechanisms according to histology in lung cancer
XIANHUA XU, JI EUN KIM, PING-LI SUN, SEOL BONG YOO, HYOJIN KIM, YAN JIN, JIN-HAENG CHUNG
Experimental and Therapeutic Medicine.2015; 9(2): 311. CrossRef
FRK Inhibits Migration and Invasion of Human Glioma Cells by Promoting N-cadherin/β-catenin Complex Formation
Qiong Shi, Xu Song, Jun Wang, Jia Gu, Weijian Zhang, Jinxia Hu, Xiuping Zhou, Rutong Yu
Journal of Molecular Neuroscience.2015; 55(1): 32. CrossRef
Dissociation of E-cadherin/β-catenin complex by MG132 and bortezomib enhances CDDP induced cell death in oral cancer SCC-25 cells
Lanhai Lü, Xiqiang Liu, Cheng Wang, Fengchun Hu, Jianning Wang, Hongzhang Huang
Toxicology in Vitro.2015; 29(8): 1965. CrossRef
Epigallocatechin-3-gallate inhibits nicotine-induced migration and invasion by the suppression of angiogenesis and epithelial-mesenchymal transition in non-small cell lung cancer cells
JINGLI SHI, FEI LIU, WENZHANG ZHANG, XIN LIU, BIHUA LIN, XUDONG TANG
Oncology Reports.2015; 33(6): 2972. CrossRef
Clinicopathologic and prognostic significance of c-MYC copy number gain in lung adenocarcinomas
A N Seo, J M Yang, H Kim, S Jheon, K Kim, C T Lee, Y Jin, S Yun, J-H Chung, J H Paik
British Journal of Cancer.2014; 110(11): 2688. CrossRef
The Clinicopathological Significance of Epithelial Mesenchymal Transition Associated Protein Expression in Head and Neck Squamous Cell Carcinoma
Kyu Ho Kim, Lucia Kim, Suk Jin Choi, Jee Young Han, Joon Mee Kim, Young Chae Chu, Young-Mo Kim, In Suh Park, Joo Han Lim
Korean Journal of Pathology.2014; 48(4): 263. CrossRef
Adenoid dysplasia of the oral mucosa
Belinda Bunn, Keith Hunter, Syed Ali Khurram, W.F.P. van Heerden
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology.2014; 118(5): 586. CrossRef
FGFR1 amplification is associated with poor prognosis and smoking in non-small-cell lung cancer
An Na Seo, Yan Jin, Hee Jin Lee, Ping-Li Sun, Hyojin Kim, Sanghoon Jheon, Kwhanmien Kim, Choon-Taek Lee, Jin-Haeng Chung
Virchows Archiv.2014; 465(5): 547. CrossRef
FNC, a Novel Nucleoside Analogue, Blocks Invasion of Aggressive Non-Hodgkin Lymphoma Cell Lines Via Inhibition of the Wnt/β-Catenin Signaling Pathway
Yan Zhang, Chen-Ping Wang, Xi-Xi Ding, Ning Wang, Fang Ma, Jin-Hua Jiang, Qing-Duan Wang, Jun-Biao Chang
Asian Pacific Journal of Cancer Prevention.2014; 15(16): 6829. CrossRef
β-Catenin overexpression is associated with gefitinib resistance in non-small cell lung cancer cells
Xia Fang, Pan Gu, Caicun Zhou, Aibin Liang, Shenxiang Ren, Fang Liu, Yu Zeng, Yunjin Wu, Yinmin Zhao, Binbin Huang, Zongmei Zhang, Xianghua Yi
Pulmonary Pharmacology & Therapeutics.2014; 28(1): 41. CrossRef
Tumor‐size‐based morphological features of metastatic lymph node tumors from primary lung adenocarcinoma
Eiji Yamada, Genichiro Ishii, Nao Aramaki, Keiju Aokage, Tomoyuki Hishida, Junji Yoshida, Motohiro Kojima, Kanji Nagai, Atsushi Ochiai
Pathology International.2014; 64(12): 591. CrossRef
Prognostic and Clinicopathological Significance of Downregulated E-Cadherin Expression in Patients with Non-Small Cell Lung Cancer (NSCLC): A Meta-Analysis
Yan-Long Yang, Ming-Wu Chen, Lei Xian, Alfons Navarro
PLoS ONE.2014; 9(6): e99763. CrossRef
Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma
Guofeng Yu, Yingying Jing, Xingrui Kou, Fei Ye, Lu Gao, Qingmin Fan, Yang Yang, Qiudong Zhao, Rong Li, Mengchao Wu, Lixin Wei, Xin-Yuan Guan
PLoS ONE.2013; 8(9): e73312. CrossRef
A Comprehensive Comparative Analysis of the Histomorphological Features of ALK-Rearranged Lung Adenocarcinoma Based on Driver Oncogene Mutations: Frequent Expression of Epithelial-Mesenchymal Transition Markers than Other Genotype
Hyojin Kim, Se Jin Jang, Doo Hyun Chung, Seol Bong Yoo, Pingli Sun, Yan Jin, Kyung Han Nam, Jin-Ho Paik, Jin-Haeng Chung, Alfredo Fusco
PLoS ONE.2013; 8(10): e76999. CrossRef
Non-small cell lung cancer cells survived ionizing radiation treatment display cancer stem cell and epithelial-mesenchymal transition phenotypes
Roberto Gomez-Casal, Chitralekha Bhattacharya, Nandita Ganesh, Lisa Bailey, Per Basse, Michael Gibson, Michael Epperly, Vera Levina
Molecular Cancer.2013;[Epub] CrossRef

First
Prev
Page of 1
Next
Last

Search